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Figure 5 Histology of the healing response to STARFlex devices. Ingrowth of tissue from the defect edges (left margin in A) covering the polyester was found after 30 days in vivo. Newly formed fibrous tissue in parallel orientation to the device surface (B, after 90 days in vivo) led to a dense avascular formation underneath the neo-endothelium with more loosely arranged fibers and capillaries in deeper layers (C, after 180 days in vivo). A mild but chronically persisting immune response with infiltration of some lymphocytes (B to D) and foreign body giant cells (arrows in D, after 1 year in vivo) is seen around the polyester fibers. H and E staining. Original magnification x2.5 (A), x5 (B), x10 (C), x20 (D).
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