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Figure 3 Comparison of the healing response to STARFlex (A, D, G), BioSTAR devices without heparin coating (B, E, H) and with heparin-coated surface (C, F, I) after 7 days in vivo. Significantly more deposits are found on the right (A, B, C) and left atrial surface (D, E, F) of STARFlex and uncoated BioSTAR devices compared to heparin coated BioSTAR devices. The histology (G, H, I) shows the level of the scaffold (< = polyester, ** = collagen matrix) and the deposition of plasma proteins and blood cells on the device (arrows). Early signs of neo-endothelial formation are observed on heparin-coated BioSTAR devices. Top row = right atrium; middle row = left atrium; bottom row = histology. RA = right atrial aspect, LA = left atrial aspect, Histo = representative histology. H and E staining. Original magnification x10 (F, G), x20 (H).
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