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Figure 3 In vivo single-photon emission computed tomography imaging and quantification of matrix metalloproteinase activity in experimental carotid lesions with the tracer, 123I-HO-CGS 27023A. Representative planar images taken 10 min (left) and 120 min (right) after injection in (A to C) apolipoprotein E-deficient (ApoE–/–) mice and (D) wild-type (WT) mice 4 weeks after carotid ligation. (A) Unblocked; (B) after pre-dosing with 6 mmol/l CGS27023A; (C) sham-operated; (D) WT; (E) quantitative uptake of the radioligand in the carotid lesion; and (F) tissue uptake over time expressed as % injected dose. *p < 0.05 between unblocked and pre-dosed lesional uptake. The signal in the abdominal cavity is non-specific and probably reflects metabolism of the original compound, because there is no inhibition after pre-dosing in all experiments. Reprinted, with permission, from Schafers et al. (21).
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