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Figure 2 In vivo gamma camera images of experimental aortic atheroma after injection of 99mtechnetium-malondialdehyde-2 (Tc-MDA2). En-face preparations of Sudan-stained aortas from an apolipoprotein E null (ApoE–/–) mouse (A) and a Watanabe heritable hyperlipidemic (WHHL) rabbit (B) injected with 125I-MDA2, a murine antibody binding to malondialdehyde–low-density lipoprotein, a model oxLDL epitope. Red color (left panels in A and B) represents plaque stained with Sudan IV, and black color (right panels in A and B) in the corresponding autoradiograph represents accumulated 125I-MDA2 reflecting the presence of oxLDL. (C) shows the relationship of 125I-MDA2 uptake and plaque burden as measured by aortic weight. (D and E) represent in vivo imaging of atherosclerotic WHHL (D) and non-atherosclerotic New Zealand White (E) rabbits with 99mTc-MDA2. Abbreviations as in Figure 1. Reprinted, with permission, from Tsimikas et al. (13).
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