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Figure 2 Thin-cap fibroatheroma. (A) Low-power view of an eccentric coronary plaque showing a thin fibrous cap overlying a relatively large necrotic core; the vessel was injected with barium (Movat Pentachrome, x20). (B) Immunohistochemical staining reveals numerous CD68-positive macrophages within the fibrous cap (rose-red reaction product, x400). (C) Shows a cellular-rich thin fibrous cap with cholesterol clefts. (D) Staining for alpha-actin positive smooth muscle cells within the fibrous cap was virtually negative (x400). (Reproduced with permission from Kolodgie FD, Virmani R, Burke AP, Farb A, et al. Pathologic assessment of the vulnerable human coronary plaque. Heart 2004;90:1385–91.)
