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Figure 3 Mitogen-activated protein kinase-mediated C-reactive protein (CRP)-induced matrix metalloproteinase (MMP)-1 (A) and MMP-10 (B) up-regulation. (A) An MEK inhibitor (PD98059) abolished the CRP-induced MMP-1 expression, whereas a p38 inhibitor (SB203580) partially reduced it. (B) Both SB203580 and SP600125 (a JNK inhibitor) blocked the CRP-induced MMP-10 up-regulation. *p < 0.05 vs. control;  p < 0.05 vs. CRP.
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