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Figure 3 Cellular imaging of macrophage metabolism using 18F-fluorodeoxyglucose (18FDG) (44). (A) Positron emission tomography (left), contrast computed tomography (middle), and offline co-registered positron emission tomography/computed tomography (right) images of a neurologically symptomatic patient who received an intravenous bolus of 18FDG (dose 370 Mbq). The positron emission tomography image demonstrates focal 18FDG uptake by a right carotid plaque (arrow), corroborated by the computed tomography angiogram and co-registered positron emission tomography/computed tomography images. (B) Relatively weaker 18FDG accumulation is seen in the carotid plaque of an asymptomatic patient. (C, D) A surgically resected carotid plaque from a symptomatic patient was incubated with tritiated deoxyglucose, an analogue of 18FDG. Autoradiography (C, original magnification x100) shows colocalization of silver grains with plaque macrophages (D, anti-CD68 antibody, x200) in areas of the fibrous cap and lipid core. Images provided courtesy of Dr. James Rudd and Dr. Peter Weissberg, Addenbrooke’s Hospital, Cambridge, United Kingdom. Reproduced by permission from reference 44.
