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Figure 3 Vasoconstrictor action of aspirate plasma in the absence (open squares/closed squares AS+/–E) and in the presence of 1 µmol/l ketanserin (5-HT2A/2C-receptor blocker) and 0.1 µmol/l pindolol (ß-adrenoceptor and 5-HT1A/1B-receptor blocker) (open diamonds/closed diamonds AS+/–E with 5-HT-R blockade) or in the presence of 1 µmol/l ketanserin, 0.1 µmol/l pindolol, and 10 µmol/l ICI 185,282 (thromboxane A2 TP-receptor blocker) (open inverted triangles/closed inverted triangles AS+/–E with 5-HT and TP-R blockade) on rat mesenteric arteries with intact (open symbols = +E) and denuded endothelium (filled symbols = –E). Values are mean ± SEM of 14 patients. *p < 0.05 vs. AS–E; #p < 0.05 vs. AS+E with Bonferroni correction for 15 comparisons.
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