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Figure 2 Schematic description of the Virtual Histology (VH) intravascular ultrasound procedure and in vitro histopathology correlation analysis for a heart rate of about 60 beats/min. After the proximal end of debulking was detected, the longitudinal distance from the proximal end to the most proximal VH image (distance 0) was calculated. Knowing the R-R interval (s) and the pullback speed of the intravascular ultrasound catheter (0.5 mm/s), the distance between each VH images was calculated as follows: distance between two VH images (mm) = R-R interval x 0.5. The distance between sections was calculated as 0.5 mm (= each distance of cutting tissue) times the ratio of pre-fixed length of tissue sample (mm) to post-fixed length (mm). The VH image that was closest to each section was chosen as the corresponding color-coded map, and the debulked area on pre-debulking VH images was predicted by comparison of pre- with post-debulking VH images. The predicted debulking area was compared visually with the histology section to assess the presence or absence of the four different components.
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