EXPEDITED REVIEW
Incomplete Neointimal Coverage of Sirolimus-Eluting Stents
Angioscopic Findings
Jun-ichi Kotani, MD, FACC*,*,
Masaki Awata, MD*,
Shinsuke Nanto, MD*,
Masaaki Uematsu, MD, FACC*,
Fusako Oshima, MD*,
Hitoshi Minamiguchi, MD*,
Gary S. Mintz, MD, FACC and
Seiki Nagata, MD*
* Cardiovascular Division, Kansai Rosai Hospital, Amagasaki, Japan
Cardiovascular Research Foundation, New York, New York
Manuscript received July 31, 2005;
revised manuscript received September 19, 2005,
accepted November 1, 2005.
* Reprint requests and correspondence: Dr. Jun-ichi Kotani, Kansai Rosai Hospital, 3-1-69 Inabaso, Amagasaki, 660-8511 Japan. (Email: shamallv8{at}aol.com).
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Abstract
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OBJECTIVES: The goal of this study was to use angioscopy to investigate the amount of neointimal coverage after sirolimus-eluting stent (SES) implantation.
BACKGROUND: Sirolimus-eluting stents reduce intimal hyperplasia.
METHODS: We used angioscopy to evaluate 37 consecutive stented coronary artery lesions (15 SES and 22 bare-metal stents [BMS]) in 25 patients (18 men, 7 women) at 3 to 6 months after stent implantation. Angioscopic evaluation focused on: 1) neointimal coverage of stent struts, and 2) the existence of thrombi. The degree of neointimal coverage was classified as grade 0 when there was no neointimal coverage (similar to immediately after the implantation); grade 1 when stent struts bulged into the lumen, but were covered and still translucently visible; grade 2 when stent struts were visible but not clearly seen (not translucent); and grade 3 when stent struts were not visible because they were embedded in the neointima.
RESULTS: Thrombi were identified in eight stented segments, tended to be more common with SES (p = 0.14), but were not seen on angiography. Three of the 15 SES (20%) had grade 0 neointimal coverage, and only 2 SES (13.3%) had complete coverage (grades 2/3). In contrast, all 22 BMS showed complete intimal coverage (grades 2/3). Thrombi were more common in stents with incomplete neointimal coverage (p = 0.09).
CONCLUSIONS: The SES had incomplete neointimal coverage three to six months after implantation, and this was associated with subclinical thrombus formation.
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Abbreviations and Acronyms
| | BMS = bare-metal stent | | IVUS = intravascular ultrasound | | SES = sirolimus-eluting stent | | VBT = vascular brachytherapy |
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Sirolimus-eluting stents (SES) have remarkably reduced restenosis by inhibiting neointimal proliferation compared with bare-metal stents (BMS) (1,2). However, similar to vascular brachytherapy (VBT), SES may have an increased rate of late thrombosis (3–8). One pathologic study has related late thrombosis to incomplete neointimal coverage (7). Angioscopy is a robust tool capable of visualizing both stent strut neointimal coverage as well as intracoronary thrombus formation in vivo (9–11). We used angioscopy to investigate the amount of neointimal coverage and thrombus formation after SES implantation compared with BMS.
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Methods
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Patient population.
We evaluated 37 consecutive stented coronary artery lesions in 25 patients (18 men and 7 women, mean age 65 years, range 54 to 78 years) who agreed to follow-up angiography and angioscopy 3 to 6 months after stent implantation. Stents were implanted using standard techniques. We compared the angioscopic findings of 15 SES-treated lesions (Cypher, Cordis, Miami Lakes, Florida) with 22 BMS (Bx Velocity, Cordis, n = 5; Driver, Medtronic, Galway, Ireland, n = 4; Zeta, Guidant, Indianapolis, Indiana, n = 8; Express 2, Boston Scientific, Natick, Massachusetts, n = 4; and Duraflex, Goodman, Galway, Ireland, n = 1). Because SES did not become available until August 2004, all patients treated before this date received BMS, and all patients treated after this date received SES. The Medical Ethics Committee at Kansai Rosai Hospital approved this study, and patients gave written informed consent. All patients received dual-antiplatelet therapy (aspirin 100 mg and ticlopidine 200 mg) after the procedure; at the time of this study, clopidogrel was not approved in Japan.
Angioscopic procedures and evaluation.
At follow-up, all stents were assessed with an 0.014-inch guidewire-compatible 4.5-F rapid-exchange coronary angioscope (Vecmova, Clinical Supply Corp., Gifu, Japan): BMS = 131 ± 48 days versus SES = 115 ± 48 days (p = NS). The system and its use have been described elsewhere (9). Briefly, all patients were given a bolus of 5,000 IU heparin intravenously before angiography and angioscopy. The optical fiber was placed at the distal segment of the coronary artery and slowly pulled back from the distal edge of the stent to the proximal edge under angioscopic and angiographic guidance.
Angioscopic evaluation focused on: 1) the degree of stent strut neointimal coverage, and 2) the existence of red or white thrombi. Neointimal coverage was classified into four grades (Fig. 1). Grade 0 was defined as stent struts that were fully visible, similar to immediately after implantation. Grade 1 was defined as stent struts that bulged into the lumen and, although covered, were still transparently visible. Grade 2 was defined as stent struts that were visible, but not clearly seen (i.e., they were translucent). Grade 3 was defined as stent struts that were not visible by angioscopy (i.e., they were embedded in the neointima). Struts that crossed side branches were excluded from grading because they all showed grade 0 coverage. (This grading system evolved from one previously reported [11].) Taken together, grade 0/1 indicated incomplete neointimal coverage, whereas grade 2/3 indicated complete coverage. In three SES and three BMS, neointimal coverage was heterogeneous; in these six cases the dominant pattern was tabulated.
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Figure 1 Angioscopic images show the grading for neointimal stent strut coverage. Neointimal coverage was more complete with bare-metal stents compared with sirolimus-eluting stents (p < 0.0001).
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Angiographic assessment.
Coronary angiography was performed in 10 regular projections, and quantitative coronary angiography performed using the CASS system (Pie Medical Imaging B.V., Maastricht, the Netherlands) with the "worst view" used to assess the severity of the stenosis (12).
Statistical analysis.
Statistical analysis was performed using StatView 5.0 (SAS Institute, Cary, North Carolina). Continuous variables were expressed as mean ± 1 SD and analyzed by unpaired Student t test or analysis of variance. Categorical variables were expressed as frequencies and analyzed by chi-square statistics or Fisher exact test (for 2 x 2 comparisons); p < 0.05 was considered significant.
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Results
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Patient and lesion characteristics.
There were no significant differences in demographics (age, gender, past history, and coronary risk factors) between patients receiving BMS versus SES (data not shown). Lesion characteristics were also similar between the two groups (Table 1). There was no difference in diabetes frequency between BMS (n = 15; 68.2%) and SES (n = 11; 73.3%) (p = 1.0). There was no significant difference in duration of dual-antiplatelet therapy between BMS (85 ± 58 days) versus SES (115 ± 47 days, p = 0.1).
Angiographic assessment.
There were no differences in quantitative coronary angiography findings between BMS and SES groups before and immediately after stent implantation (Table 2). At follow-up, the SES group had a larger minimal lumen diameter than the BMS group (Table 2). Therefore, late loss was significantly higher in BMS than in SES group (0.8 ± 0.6 mm in BMS vs. 0.2 ± 0.4 mm in SES, p = 0.0013).
Angioscopic findings.
Thrombi were identified in eight stented segments. All were mural thrombi, none were occlusive, and none were detectable by angiography. Five red thrombi were detected in 15 SES (33%), whereas 2 red thrombi and 1 white thrombus were detected in 22 BMS (14%), p = 0.14.
Angioscopic grades of neointimal coverage were markedly different between BMS and SES (p < 0.0001) (Fig. 1). Three of 15 SES (20%) had grade 0 coverage, and only 2 (13.3%) had complete coverage (grades 2/3). In contrast, all 22 BMS had complete intimal coverage (grades 2/3). The grade of neointimal coverage was related to the duration of follow-up in BMS (p = 0.058), but not in SES (p = 1.0).
The relationship between the degree of neointimal coverage and the presence of thrombi is shown in Table 3. In the entire cohort of 37 stented lesions, there was a tendency for thrombi to be correlated with incomplete neointimal coverage (p = 0.09 by Fisher exact test).
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Discussion
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The present study showed significant differences between neointimal coverage of BMS versus SES three to six months after implantation. All BMS had complete neointimal coverage, whereas neointima covering of SES struts was more lucent and less complete. Furthermore, incomplete neointimal coverage was associated with thrombus formation that tended to be more common in SES than in BMS.
Intravascular ultrasound (IVUS) studies showed that in-stent restenosis was secondary to neointimal hyperplasia. Earlier angioscopic studies showed that complete neointimal coverage was the rule in BMS (9–11). The IVUS studies also showed that drug-eluting stents reduced in-stent restenosis by inhibiting neointimal hyperplasia. Furthermore, one previous IVUS study showed that nonpolymeric paclitaxel-eluting stents not only inhibited intimal hyperplasia, but also increased the neointimal-free length of the stents; the length of stent that was free of IVUS-detectable intimal hyperplasia measured 3.2 ± 4.8 mm in placebo stents, 6.1 ± 5.6 mm in low-dose stents, and 8.7 ± 6.1 mm in high-dose stents (p = 0.0029) (13). The current study extended these observations by showing that SES not only suppressed intimal hyperplasia, but also left a significant portion of the stent struts fully exposed and uncovered, similar to immediately after implantation.
In the current study, the lack of neointimal strut coverage was associated with thrombus formation. One previous pathological study reported that impaired healing (i.e., failure to form a complete neointimal layer over the stent struts) extended the window during which stents were prone to thrombosis (7), and VBT also inhibited neointimal growth. In patients treated with VBT, the lack of re-endothelialization and late thrombosis were related, especially in the setting of new stent implantation (7,14). On the other hand, prolonged intensive antiplatelet therapy or reduced restenting when treating in-stent restenosis with VBT decreased the late stent thrombosis rate (8).
One earlier serial angioscopic study showed that intimal coverage of BMS proceeded gradually with subsequent neointimal remodeling (shrinkage) up to two years (11). Similarly, in the current analysis the grade of neointimal coverage in BMS was related to the time from implantation to angioscopic follow-up even though all angioscopic studies were performed within six months. A recent case report on the pathology of SES-treated lesions showed that endothelial coverage was >80% complete after 16 months (15). In the current study, neointimal coverage was unrelated to the time from DES implantation to angioscopic follow-up when all follow-up studies were performed within six months; therefore, the time course for neointimal coverage is more prolonged than with BMS. On the other hand, late catch-up after VBT has been well shown, and SES may have a similar late catch-up potential (16,17). Longer-term serial angioscopic observations will be necessary to clarify the chronological findings; however, these data may be difficult to obtain.
Study limitations.
The structural designs of the stents used in our study were not identical between the BMS and the SES groups. Therefore, we could not exclude effects of mechanical designs on the angioscopic findings. This was not a serial study; therefore, we could not compare the chronological course of neointimal coverage between BMS and SES. All angioscopic studies were performed within six months after implantation, and the interval from implantation to follow-up ranged from three to six months. Longer-term study (beyond 12 months) will be required to address the issue of late, late thrombosis. Finally, this study only investigated neointimal morphology; local endothelial function remained unclear; and grade 1 with a functional neointima might be as good as grade 2 or 3 coverage.
Conclusions.
Angioscopic findings of neointimal coverage within six months after implantation were quite different between BMS and SES. The SES had incomplete neointimal coverage three to six months after implantation, and this was associated with subclinical thrombus formation. This supports prolonged dual-antiplatelet therapy for patients treated with SES.
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Acknowledgments
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The authors gratefully acknowledge Mr. Kenji Yamamoto and Mr. Teruo Nakatsuka for recording angioscopic images.
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Footnotes
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This research was partly supported by the Japan Labour, Health, and Welfare Organization.
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Feasibility, Safety, and Efficacy of a Novel Polymeric Pimecrolimus-Eluting Stent: Traditional Pre-Clinical Safety End Points Failed to Predict 6-Month Clinical Angiographic Results
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October 1, 2009;
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[Abstract]
[Full Text]
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K. Waseda, A. Miyazawa, J. Ako, T. Hasegawa, I. Tsujino, R. Sakurai, P. G. Yock, Y. Honda, D. E. Kandzari, M. B. Leon, et al.
Intravascular Ultrasound Results From the ENDEAVOR IV Trial: Randomized Comparison Between Zotarolimus- and Paclitaxel-Eluting Stents in Patients With Coronary Artery Disease
J. Am. Coll. Cardiol. Intv.,
August 1, 2009;
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[Abstract]
[Full Text]
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Y. Onuma, N. Kukreja, N. Piazza, J. Eindhoven, C. Girasis, L. Schenkeveld, R. van Domburg, P. W. Serruys, and Interventional Cardiologists of the Thoraxcenter (
The Everolimus-Eluting Stent in Real-World Patients: 6-Month Follow-Up of the X-SEARCH (Xience V Stent Evaluated at Rotterdam Cardiac Hospital) Registry
J. Am. Coll. Cardiol.,
July 14, 2009;
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[Abstract]
[Full Text]
[PDF]
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F. Alfonso, M.-J. Perez-Vizcayno, M. Ruiz, A. Suarez, M. Cazares, R. Hernandez, J. Escaned, C. Banuelos, P. Jimenez-Quevedo, and C. Macaya
Coronary Aneurysms After Drug-Eluting Stent Implantation: Clinical, Angiographic, and Intravascular Ultrasound Findings
J. Am. Coll. Cardiol.,
June 2, 2009;
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[Abstract]
[Full Text]
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J. A. Ormiston and P. W.S. Serruys
Bioabsorbable Coronary Stents
Circ Cardiovasc Interv,
June 1, 2009;
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T. Higo, Y. Ueda, J. Oyabu, K. Okada, M. Nishio, A. Hirata, K. Kashiwase, N. Ogasawara, S. Hirotani, and K. Kodama
Atherosclerotic and thrombogenic neointima formed over sirolimus drug-eluting stent an angioscopic study.
J. Am. Coll. Cardiol. Img.,
May 1, 2009;
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[Abstract]
[Full Text]
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G. Nakazawa, M. Vorpahl, A. V. Finn, J. Narula, and R. Virmani
One step forward and two steps back with drug-eluting-stents from preventing restenosis to causing late thrombosis and nouveau atherosclerosis.
J. Am. Coll. Cardiol. Img.,
May 1, 2009;
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Y. Suzuki, A. C. Yeung, and F. Ikeno
The Pre-Clinical Animal Model in the Translational Research of Interventional Cardiology
J. Am. Coll. Cardiol. Intv.,
May 1, 2009;
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[Abstract]
[Full Text]
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M. Awata, S. Nanto, M. Uematsu, T. Morozumi, T. Watanabe, T. Onishi, O. Iida, F. Sera, H. Minamiguchi, J.-i. Kotani, et al.
Heterogeneous Arterial Healing in Patients Following Paclitaxel-Eluting Stent Implantation: Comparison With Sirolimus-Eluting Stents
J. Am. Coll. Cardiol. Intv.,
May 1, 2009;
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[Abstract]
[Full Text]
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H. Otake, J. Shite, J. Ako, T. Shinke, Y. Tanino, D. Ogasawara, T. Sawada, N. Miyoshi, H. Kato, B.-K. Koo, et al.
Local Determinants of Thrombus Formation Following Sirolimus-Eluting Stent Implantation Assessed by Optical Coherence Tomography
J. Am. Coll. Cardiol. Intv.,
May 1, 2009;
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[Abstract]
[Full Text]
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B. E. Stahli, G. G. Camici, and F. C. Tanner
Drug-eluting stent thrombosis
Therapeutic Advances in Cardiovascular Disease,
February 1, 2009;
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[Abstract]
[PDF]
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J. P. Chen, L. V. Crisco, R. Jabara, and S. B. King III
Late Angiographic Stent Thrombosis: The LAST Straw for Drug-Eluting Stents?
Angiology,
January 1, 2009;
59(6):
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[Abstract]
[PDF]
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A. K. Chhatriwalla and D. L. Bhatt
Should dual antiplatelet therapy after drug-eluting stents be continued for more than 1 year?: Dual Antiplatelet Therapy After Drug-Eluting Stents Should Be Continued for More Than One Year and Preferably Indefinitely
Circ Cardiovasc Interv,
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P. Wenaweser, J. Daemen, M. Zwahlen, R. van Domburg, P. Juni, S. Vaina, G. Hellige, K. Tsuchida, C. Morger, E. Boersma, et al.
Incidence and Correlates of Drug-Eluting Stent Thrombosis in Routine Clinical Practice: 4-Year Results From a Large 2-Institutional Cohort Study
J. Am. Coll. Cardiol.,
September 30, 2008;
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[Abstract]
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M. E. Pfisterer
Late Stent Thrombosis After Drug-Eluting Stent Implantation for Acute Myocardial Infarction: A New Red Flag Is Raised
Circulation,
September 9, 2008;
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[Full Text]
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T. Miyake, M. Aoki, and R. Morishita
Inhibition of anastomotic intimal hyperplasia using a chimeric decoy strategy against NF{kappa}B and E2F in a rabbit model
Cardiovasc Res,
September 1, 2008;
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[Abstract]
[Full Text]
[PDF]
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M. Awata, S. Nanto, M. Uematsu, T. Morozumi, T. Watanabe, T. Onishi, O. Iida, F. Sera, J.-i. Kotani, M. Hori, et al.
Angioscopic Comparison of Neointimal Coverage Between Zotarolimus- and Sirolimus-Eluting Stents
J. Am. Coll. Cardiol.,
August 26, 2008;
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[Full Text]
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M. Takano, M. Yamamoto, D. Murakami, S. Inami, K. Okamatsu, K. Seimiya, T. Ohba, Y. Seino, and K. Mizuno
Lack of Association Between Large Angiographic Late Loss and Low Risk of In-Stent Thrombus: Angioscopic Comparison Between Paclitaxel- and Sirolimus-Eluting Stents
Circ Cardiovasc Interv,
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[Abstract]
[Full Text]
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T. Shinke, J. Li, J. P. Chen, L. Pendyala, T. Goodchild, R. Jabara, S. Geva, T. Ueno, N. Chronos, K. Robinson, et al.
High Incidence of Intramural Thrombus After Overlapping Paclitaxel-Eluting Stent Implantation: Angioscopic and Histopathologic Analysis in Porcine Coronary Arteries
Circ Cardiovasc Interv,
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[Abstract]
[Full Text]
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L. T. Newsome, M. A. Kutcher, and R. L. Royster
Coronary Artery Stents: Part I. Evolution of Percutaneous Coronary Intervention
Anesth. Analg.,
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[Abstract]
[Full Text]
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M. J. Kern and J. Narula
Looking into the vessel: the more you see, the more you want to see.
J. Am. Coll. Cardiol. Img.,
July 1, 2008;
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E. Mahmud, G. Bromberg-Marin, V. Palakodeti, L. Ang, D. Creanga, and A. N. DeMaria
Clinical Efficacy of Drug-Eluting Stents in Diabetic Patients: A Meta-Analysis
J. Am. Coll. Cardiol.,
June 24, 2008;
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[Abstract]
[Full Text]
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J. Sullivan and N. Amarshi
Dual antiplatelet therapy with clopidogrel and aspirin
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[Abstract]
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M. I. Hamilos, M. Ostojic, B. Beleslin, D. Sagic, L. Mangovski, S. Stojkovic, M. Nedeljkovic, D. Orlic, B. Milosavljevic, D. Topic, et al.
Differential Effects of Drug-Eluting Stents on Local Endothelium-Dependent Coronary Vasomotion
J. Am. Coll. Cardiol.,
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[Abstract]
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G. W. Stone, M. Midei, W. Newman, M. Sanz, J. B. Hermiller, J. Williams, N. Farhat, K. W. Mahaffey, D. E. Cutlip, P. J. Fitzgerald, et al.
Comparison of an Everolimus-Eluting Stent and a Paclitaxel-Eluting Stent in Patients With Coronary Artery Disease: A Randomized Trial
JAMA,
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[Abstract]
[Full Text]
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Y. Honda and P. J. Fitzgerald
Frontiers in Intravascular Imaging Technologies
Circulation,
April 15, 2008;
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[Full Text]
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F. Saia, A. Marzocchi, and A. Branzi
Review: The safety of drug-eluting stents
Therapeutic Advances in Cardiovascular Disease,
February 1, 2008;
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[Abstract]
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J. Aoki, A. Kirtane, M. B. Leon, and G. Dangas
Coronary artery aneurysms after drug-eluting stent implantation.
J. Am. Coll. Cardiol. Intv.,
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[Abstract]
[Full Text]
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T. G. Nuhrenberg, N. Langwieser, J. B.K. Schwarz, Y. Hou, P. Frank, F. Sorge, S. Matschurat, S. Seidl, A. Kastrati, A. Schomig, et al.
EMAP-II downregulation contributes to the beneficial effects of rapamycin after vascular injury
Cardiovasc Res,
February 1, 2008;
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580 - 589.
[Abstract]
[Full Text]
[PDF]
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B. Doyle, C. S. Rihal, C. J. O'Sullivan, R. J. Lennon, H. J. Wiste, M. Bell, J. Bresnahan, and D. R. Holmes Jr
Outcomes of Stent Thrombosis and Restenosis During Extended Follow-Up of Patients Treated With Bare-Metal Coronary Stents
Circulation,
November 20, 2007;
116(21):
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[Abstract]
[Full Text]
[PDF]
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S. Windecker and B. Meier
Late Coronary Stent Thrombosis
Circulation,
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A. E. Rodriguez, A. O. Maree, J. Mieres, D. Berrocal, L. Grinfeld, C. Fernandez-Pereira, V. Curotto, A. Rodriguez-Granillo, W. O'Neill, and I. F. Palacios
Late loss of early benefit from drug-eluting stents when compared with bare-metal stents and coronary artery bypass surgery: 3 years follow-up of the ERACI III registry
Eur. Heart J.,
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[Abstract]
[Full Text]
[PDF]
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P.-G. Chassot, A. Delabays, and D. R. Spahn
Perioperative antiplatelet therapy: the case for continuing therapy in patients at risk of myocardial infarction
Br. J. Anaesth.,
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[Abstract]
[Full Text]
[PDF]
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J. Daemen and P. W. Serruys
Drug-Eluting Stent Update 2007: Part II: Unsettled Issues
Circulation,
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[Full Text]
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M. Awata, J.-i. Kotani, M. Uematsu, T. Morozumi, T. Watanabe, T. Onishi, O. Iida, F. Sera, S. Nanto, M. Hori, et al.
Serial Angioscopic Evidence of Incomplete Neointimal Coverage After Sirolimus-Eluting Stent Implantation: Comparison With Bare-Metal Stents
Circulation,
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116(8):
910 - 916.
[Abstract]
[Full Text]
[PDF]
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J. L. Anderson, C. D. Adams, E. M. Antman, C. R. Bridges, R. M. Califf, D. E. Casey Jr, W. E. Chavey II, F. M. Fesmire, J. S. Hochman, T. N. Levin, et al.
ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine
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J. L. Anderson, C. D. Adams, E. M. Antman, C. R. Bridges, R. M. Califf, D. E. Casey Jr, W. E. Chavey II, F. M. Fesmire, J. S. Hochman, T. N. Levin, et al.
ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine
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August 14, 2007;
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652 - 726.
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M. R Bennett
Vascular pathology as a result of drug-eluting stents
Heart,
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[Abstract]
[Full Text]
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C. Bode and M. Zehender
The use of antiplatelet agents following percutaneous coronary intervention: focus on late stent thrombosis
Eur. Heart J. Suppl.,
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[Abstract]
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S. R. Dixon, C. L. Grines, and W. W. O'Neill
The Year in Interventional Cardiology
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R. Jaffe and B. H. Strauss
Late and Very Late Thrombosis of Drug-Eluting Stents: Evolving Concepts and Perspectives
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[Abstract]
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D. R. Holmes Jr, D. J. Kereiakes, W. K. Laskey, A. Colombo, S. G. Ellis, T. D. Henry, J. J. Popma, P. W.J.C. Serruys, T. Kimura, D. O. Williams, et al.
Thrombosis and Drug-Eluting Stents: An Objective Appraisal
J. Am. Coll. Cardiol.,
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A. V. Finn, G. Nakazawa, M. Joner, F. D. Kolodgie, E. K. Mont, H. K. Gold, and R. Virmani
Vascular Responses to Drug Eluting Stents: Importance of Delayed Healing
Arterioscler Thromb Vasc Biol,
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[Abstract]
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D. Matsumoto, J. Shite, T. Shinke, H. Otake, Y. Tanino, D. Ogasawara, T. Sawada, O. L. Paredes, K.-i. Hirata, and M. Yokoyama
Neointimal coverage of sirolimus-eluting stents at 6-month follow-up: evaluated by optical coherence tomography
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B. J.G.L. de Smet and F. Zijlstra
A look at drug eluting stents with optical coherence tomography
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E. Camenzind, P. G. Steg, and W. Wijns
A Cause for Concern
Circulation,
March 20, 2007;
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H.-P. B.-L. Rocca, C. Kaiser, M. Pfisterer, and on behalf of the BASKET Investigators
Targeted stent use in clinical practice based on evidence from the BAsel Stent Cost Effectiveness Trial (BASKET)
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D. I. Simon and V. J. Pompili
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Circulation,
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A. N. DeMaria, O. Ben-Yehuda, G. K. Feld, G. S. Ginsburg, B. H. Greenberg, W. Y.W. Lew, J. A.C. Lima, A. S. Maisel, J. Narula, D. J. Sahn, et al.
Highlights of the Year in JACC 2006
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D. J. Kereiakes
Does Clopidogrel Each Day Keep Stent Thrombosis Away?
JAMA,
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M. Pfisterer, H. P. Brunner-La Rocca, P. T. Buser, P. Rickenbacher, P. Hunziker, C. Mueller, R. Jeger, F. Bader, S. Osswald, C. Kaiser, et al.
Late Clinical Events After Clopidogrel Discontinuation May Limit the Benefit of Drug-Eluting Stents: An Observational Study of Drug-Eluting Versus Bare-Metal Stents
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P. J. Geraghty
Bioabsorbable Stenting for Peripheral Arterial Occlusive Disease
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S. Tsimikas
Drug-Eluting Stents and Late Adverse Clinical Outcomes: Lessons Learned, Lessons Awaited
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Top
Abstract
Methods