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Figure 1 Mechanistic hypothesis of the efficacy of skeletal myoblast transplantation on chronic ischemic mitral regurgitation (MR). (Left) Baseline configuration of left ventricle (LV) with normal mitral leaflet closure. (Middle) Chronic infero-posterior infarction: loss of viable myocardial cells induce local LV remodeling with outward bulging of the free wall, papillary muscle displacement, and increased leaflet tethering and MR. (Right) Myoblast transplantation reverses local remodeling with decreased tethering distance and improved leaflet coaptation and MR. Ao = aorta; Ant. = anterior; LA = left atrium; MI = myocardial infarction; Post. = posterior.
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