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Figure 4 Changes in the two-dimensional and three-dimensional structure of platelet thrombi exposed to blood containing antiplatelet agents. These experiments were performed essentially as described in the caption of Figure 3. (A) Representative two-dimensional fluorescence microscopy images of platelet thrombi immediately after perfusion of the first control blood aliquot (0 min) or at different times after beginning the second perfusion with either untreated blood (No Addition) or blood containing tirofiban (0.5 µmol/l), as indicated (please see the online version of this article for supplemental videos). (B) Cross-sectional area of thrombi at the indicated distances from the collagen surface after perfusion of untreated blood for 6 min (No Addition), or after perfusion for an additional 6 min of blood containing aspirin (100 µmol/l) or tirofiban (0.5 µmol/l), as indicated. See Figure 3C for additional details.
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