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Figure 7 (A) Identification of MEFA2A mutation P279L in coronary artery disease (CAD) patient GB00305. (B) Structure of MEF2A protein with CAD/myocardial infarction-associated mutations indicated. The MEFA2A gene consists of 11 exons and encodes a 507 amino acid protein. The MCMI agamous deficiens serum response factor (MADS) domain and MEF2 domain at the N-terminal region are responsible for DNA binding, dimerization, and interaction with other transcription factor. The transcription activation domain is located in the middle portion, and the C-terminal region is responsible for nuclear localization site (NLS) (with permission from Bhagavatula et al. [37]).
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