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Figure 5 (A) Haseman-Elston sib-pair regression analysis for scanning loci segregating with myocardial infarction. The vertical axis of each plot is –log10(P) or pP, where the P is the significance level from each of two analyses. The solid line denotes the multipoint linkage profile for all pedigrees; the broken dotted/dashed line denotes the multipoint linkage profile for Caucasian-only pedigrees. The horizontal solid line in each subfigure indicates P = 2.2 x 10–5 (–log10(P) = 4.66 or logarithm of the odds ratio score = 3.6). The x axis denotes marker map positions. Note that the dashed line (p values for Caucasians only) is often not visible because it frequently overlaps with the solid line (p values for all study families). (B) Identification of a novel genetic linkage for myocardial infarction on chromosome 1p34-36. The vertical axis represents the –log10(P value) or pP, and the horizontal axis denotes the distance (cM) with markers along the chromosome. The results were obtained by multipoint linkage analysis of 2 cM intervals using the S.A.G.E. package (Statistical Analysis for Genetic Epidemiology, Statistical Solutions, Cork, Ireland). The asymptotic p values were quoted accurately to only 12 decimal places, resulting in a flat pP peak (with permission from Wang et al. [1]).
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