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Figure 2 (A) QT-RR (open circles) intervals of patients under sotalol (1 to 9.9 mg/kg/day) therapy. Filled circles = a 50-day-old infant (4.1 mg/kg/day); large filled circles = 8-year-old child (2.9 mg/kg/day). Solid line = fit of baseline neonate/infant QT-RR data dotted line: a fit of baseline children/adolescent data. (B) Differences of QTcPOP intervals from baseline in neonates (filled circles) and all other pediatric patients (open circles) versus sotalol concentration. (C) Sensitivity of the QTc interval prolongation towards sotalol (dQTcPOP).
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