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Figure 4 Apical four-chamber-view echocardiograms (top row) and cross-sectional views of cardiac single-photon emission computed tomography (SPECT) (bottom row) in two patients with transthyretin (TTR)-related cardiac amyloidosis. Topographic correspondences between increased left ventricular parietal thickness and 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD) uptake is evident: (A) increased thickness of both the interventricular septum and the lateral wall of the left ventricle at echocardiography in correspondence with diffuse myocardial 99mTc-DPD uptake at SPECT; (B) increased thickness of the medial portion of the interventricular septum (with normal lateral wall) at echocardiography in correspondence with localized myocardial 99mTc-DPD uptake at the same level. IVS = intraventricular septum; LA = left atrium; LV = left ventricle; RA = right atrium; RV = right ventricle.
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