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Figure 2 (A) Tissue factor antigen in microparticle pTF (mpTF) and supernatant pTF (spTF) derived from the same wound pTF processed as described by Nieuwland et al. (16) (filled bars) or Bogdanov et al. (17) (open bars). p = 0.021, mpTF versus spTF, filled bars; p = 0.00041, mpTF versus spTF, open bars, n = 4). (B) fVIIa generated from unstimulated and C5a-stimulated donor mononuclear cells incubated with 1.46 pmoles/l of wound pTF, wound microparticle TF (mpTF) or wound supernatant TF (spTF) (n = 3). p values for fVIIa production between stimulated and unstimulated monocytes are 0.002, wound mpTF; 0.043, wound spTF; and 0.069, wound pTF. p values for wound mpTF versus wound spTF or wound pTF for stimulated and unstimulated monocytes ranged from 0.000 to 0.005; p values for wound spTF versus wound pTF were 0.270 and 0.407. Solid bars = unstimulated; open bars = stimulated. Abbreviations as in Figure 1.
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