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Figure 2 Aggregation curves from a normal individual, obtained after the addition of adenosine 5'-diphosphate (ADP) 2.5 µM and thrombin receptor agonist peptide (TRAP) 2.5 µM in platelet-rich plasma at baseline (left); 24 h after a loading dose of clopidogrel (middle); and 24 h later, after a dose of clopidogrel 75 mg and aspirin (ASA) 300 mg (right). Disintegration is minimal at baseline and nearly complete after clopidogrel in the presence of ADP and significant in the presence of TRAP. Aspirin added no additional disintegration.
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