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Figure 1 The study design. Subjects randomized to the 5-mg dose group received 2.5 mg for 2 weeks and 5 mg for 10 weeks. Subjects randomized to the 10-mg dose group received 2.5 mg for 2 weeks, 5 mg for 2 weeks, and 10 mg for 8 weeks. Dose adjustments were allowed during the optional open-label extension period (weeks 13 to 24).
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