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Figure 3 HIF-1 (+) transgenic hearts show increased expression of HIF-1, VEGF, and iNOS in the peri-infarct region compared to control HIF-1(–) hearts. (A) Western blot analysis of HIF-1, VEGF, and iNOS in infarct, peri-infarct, and remote left ventricular regions at 24 h and 4 weeks after LAD ligation and in sham-operated hearts. + = HIF-1(+) hearts; –= HIF-1(–) hearts. (B) Immunohistochemical localization of HIF-1, VEGF, and iNOS protein in peri-infarct areas at 4 weeks in HIF-1(+) and HIF-1 (–) hearts. Sections were counterstained with hematoxylin. Scale bar = 80 µm.
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