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Figure 2 Northern blot analysis of transgenic and endogenous HIF-1{alpha} in infarct, peri-infarct, and remote left ventricular regions at 24 h and 4 weeks after LAD ligation and in sham-operated hearts. + = HIF-1{alpha}(+) hearts; – = HIF-1{alpha}(–) hearts. Steady-state levels of transgenic HIF-1{alpha} mRNA are not affected by hypoxic conditions, while steady-state levels of endogenous HIF-1{alpha} mRNA are increased in early infarct and peri-infarct regions.





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