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Figure 2 Marginal analysis of non-inferiority for Stroke Prevention Using Oral Thrombin Inhibitor in Atrial Fibrillation (SPORTIF) trial. Data are shown as point estimates and 95% confidence interval (CI) for absolute (left) and relative (right) difference in outcome for intention-to-treat (ITT) and on-treatment (OT) populations. The vertical dashed lines represent non-inferiority margins. Non-inferiority is established when the upper bound of the two-sided 95% CI (equivalent to one-sided 97.5% CI) is less than the margin. Superiority is established if the upper bound lies below 0 absolute difference (or <1.0 risk ratio).
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