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Figure 2 Enzymatic and protein changes within high-density lipoprotein (HDL) during an acute phase reaction. Serum amyloid A (SAA), apolipoprotein J (J), and secretory nonpancreatic phospholipase A2 (sPLA2) are present at higher serum concentrations and incorporate into HDL, while the HDL components apolipoprotein A-I (A-I), paraoxonase 1 (PON1), platelet activating factor acyl hydrolase (PAF-AH), cholesteryl ester transfer protein (CETP), lecithin:cholesterol acyltransferase (LCAT), and phospholipid transfer protein (PLTP) all decrease in concentration within HDL. High-density lipoprotein phospholipid content also falls, along with a reduction in cholesterol esters and an increase in triglycerides, free fatty acids, and free cholesterol. A-II = apolipoprotein A-II. From Rohrer et al. (31).
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