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Figure 3 Electron micrographic observation of the aortic valves of senile ApoE–/– mice. (A and B) Electron micrographs of the aortic valve of a 50-week-old ApoE–/– mouse. There are a macrophage (A, left), an osteoblast-like cell (A, right), and a smooth muscle-like cell (B). Scale bar = 5µm. (C) A macrophage observed in the valve leaflet (A). Scale bar = 1µm. (D) Higher magnification image of a smooth muscle-like cell (B) that has muscle fibers, basement membrane, and mitochondria. Scale bar = 1µm. (E) An osteoblast-like cell (A) that has a well-developed Golgi apparatus and rough endoplasmic reticulum. Scale bar = 1µm. (F) Calcium deposition in the sclerotic valve leaflet. Scale bar = 1µm.
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