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J Am Coll Cardiol, 2005; 45:1309, doi:10.1016/j.jacc.2005.01.023
© 2005 by the American College of Cardiology Foundation
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CORRESPONDENCE: LETTERS TO THE EDITOR

Cardiac complications of vaccines

Serdar Kula, MD*, Berna Canter, MD, Fatma Sedef Tunaoglu, MD and Rana Olgunturk, MD

* Gazi University, School of Medicine, 06500, Besevler, Ankara, Turkey (Email: kula{at}gazi.edu.tr).

We read with interest the recent study by Eckart et al. (1) entitled "Incidence and Follow-Up of Inflammatory Cardiac Complications After Smallpox Vaccination." Although smallpox is the most common vaccine that is associated with myocarditis, other vaccines have also been linked with myocarditis, such as diphtheria-tetanus-polio vaccine, tetanus vaccine alone, cholera, typhoid-cholera, and variola vaccines (2–6). In order to assess any relationship between smallpox vaccination and myocarditis more accurately, it would be essential to know what other vaccines were administered to the military personnel in the study. Moreover, was there any relationship between specific lot numbers and myocarditis?


   References
Top
 References
 
1. Eckart RE, Love SS, Atwood JE, et al. Incidence and follow-up of inflammatory cardiac complications after smallpox vaccination J Am Coll Cardiol 2004;44:201-205.[Abstract/Free Full Text]

2. Dilber E, Karagoz T, Aytemir K, et al. Acute myocarditis associated with tetanus vaccination Mayo Clin Proc 2003;78:1431-1433.[Free Full Text]

3. Boccara F, Benhaiem-Sigaux N, Cohen A. Acute myopericarditis after diphtheria, tetanus, and polio vaccination Chest 2001;120:671-672.[Abstract/Free Full Text]

4. Driehorst J, Laubenthal F. Acute myocarditis after cholera vaccination Dtsch Med Wochenschr 1984;109:197-198.[Medline]

5. Mittermayer CH. Lethal complications of typhoid-cholera-vaccination(case report and review of the literature) Beitr Pathol 1976;158:212-224.[Web of Science][Medline]

6. Apostolski A, Stankovic M, Romano M, Anicic S, Popovic D. Myocarditis following administration of antivariola vaccine Vojnosanit Pregl 1974;31:122-125.[Medline]


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Robert E. Eckart, J. Edwin Atwood, and John D. Grabenstein
J. Am. Coll. Cardiol. 2005 45: 1309-1310. [Full Text] [PDF]




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