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Figure 8 (a) Ischemia/reperfusion (I/R)-induced LV infarct size in dogs in vivo. Hydroxyfasudil significantly reduced the I/R-induced LV infarct size. The beneficial effect of hydroxyfasudil was partially attenuated by L-NMMA, while L-NMMA alone did not significantly increase the infarct size. Number of animals used was each 7 for C, HF, and L + HF, and 4 for L. C = control; L = L-NMMA; HF = hydroxyfasudil. **p < 0.01. (b) Plot of infarct size expressed as a percentage of the risk area and regional collateral flow during ischemia. In the control group, there was an inverse relation between infarct area and collateral flow measured by microsphere (r = 0.93, p < 0.01), and hydroxyfasudil significantly shifted the regression line downward as compared with the control group (p < 0.01). Number of animals used was five for control conditions and four for hydroxyfasudil.
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