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Figure 6 Endothelium-independent coronary vasodilation before and after coronary I/R injury in dogs in vivo. Coronary vasodilator response to papaverine was comparable under all conditions in both small arteries and arterioles. Number of vessels per animals used was 7/6 for control (mean diameter 120 ± 7 µm), 5/4 for L-NMMA (123 ± 8 µm), 6/4 for hydroxyfasudil (118 ± 8 µm), and 5/4 for hydroxyfasudil plus L-NMMA (125 ± 9 µm) in small arteries; and 12/6 for control (70 ± 6 µm), 8/4 for L-NMMA (69 ± 7 µm), 8/5 for hydroxyfasudil (68 ± 7 µm), and 11/6 for hydroxyfasudil plus L-NMMA (71 ± 5 µm) in arterioles. C = control; L = L-NMMA; HF = hydroxyfasudil. I/R = ischemia/reperfusion. B = before papaverine; A = after papaverine.
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