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Figure 2 Coronary vasodilator effects of hydroxyfasudil in dogs in vivo. Hydroxyfasudil (10, 30, and 100 µg/kg, IC) caused coronary vasodilation, in a dose-dependent manner, under normal conditions in both small arteries (a) and arterioles (b). Number of vessels per animal used was 5/3 in small arteries and 7/4 in arterioles, respectively. Hydroxyfasudil also increased coronary blood flow (CBF) in a dose-dependent manner (c). *p < 0.05.
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