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Figure 3 (A) Measurement of mean myocardial enhancement extent by contrast-enhanced magnetic resonance imaging (CeMRI) (adjusted inversion time [TI]) over time based on different threshold analysis in comparison with remote myocardium and mean Tc99m-sestamibi single-photon emission computed tomography (SPECT) perfusion defect. (B) Mean myocardial enhancement extent by CeMRI over time based on a threshold analysis of >200% of remote myocardium. If the TI was held constant at 300 ms, the mean enhancement size significantly decreased on acquisitions after the 28th min postcontrast in comparison with CeMRI performed with an adjusted TI (p < 0.03). (C) Mean difference of CeMRI and SPECT over time. Mean difference was calculated between the size of myocardial contrast-enhancement by CeMRI based on a threshold >200% of remote myocardium and the size of SPECT perfusion defect within every patient. Using an adjusted TI CeMRI and SPECT showed a good agreement at all time points within an average difference of 3% of the left ventricular (LV) myocardium. For a constant TI of 300 ms, both modalities agreed well until 21 min after contrast injection; however, on later acquisitions the mean difference increased to about 7% of the LV myocardium at 42 min (p < 0.03).
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