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Figure 6 Effect of both IKr and IKs suppression on the simulated action potentials from the epicardial (Epi), midmyocardial (M), and endocardial (Endo) cells. (A) Superimposed action potentials simulated under baseline condition (dotted lines) and after both IKr and IKs suppression (70% and 80%, respectively) (solid lines). (B) Effect of maximum conductance of Ito (Gto) on the simulated epicardial action potential (Vm), ICa,L magnitude, and the net charge entry calculated by integration of the ICa,L under the condition of both IKr and IKs suppression. Basic cycle length = 2,000 ms. EAD = early afterdepolarization.
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