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Figure 5 Detection of IKr and IKs in the epicardial (Epi), midmyocardial (M), and endocardial (Endo) cells. Depolarizing test pulses (to +30 mV for 300 ms) were repetitively applied (every 2 s) from a holding potential of –50 mV to activate IK, and membrane currents were recorded from the Epi, M, and Endo cells, before (trace 1), and  2 min after exposure to 3 µmol/l E-4031 (trace 2), and 2 min after further addition of 30 µmol/l 293B in conjunction with 3 µmol/l E-4031 (trace 3). pA = pico (x 10–12) Ampere.
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