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Figure 3 Dose-dependent effect of Verap (0.1 to 5 µmol/l) on transmembrane and ECG activity under acquired LQTS condition (293B 10 µmol/l + E-4031 1 µmol/l). (A) Superimposed action potentials recorded simultaneously from the epicardial and M regions together with a transmural ECG. (B) Composite data of the effect of Verap on QT interval (solid squares), action potential duration measured at 90% repolarization (APD90) of Epi (open triangles) and M (open circles) regions and transmural dispersion of repolarization (TDR) (solid diamonds). Basic cycle length = 2,000 ms. *p < 0.05 vs. 293B + E-4031;  p < 0.01 vs. 293B + E-4031; ¶p < 0.05 vs. M region by analysis of variance with Bonferroni's test. Abbreviations as in Figure 1.
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