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Figure 7 (A, left upper panels) Histopathologic findings (hematoxylin-eosin) of the anterior wall of the rats with 12-week CS and with HCD (A-1, magnification x40) and NCD (A-2, magnification x40), as well as MCP-1–positive coronary microvessels and infiltrating cells in rats with HCD (A-3, magnification x200). (B, right upper panel, and C, right lower panel) MCP-1 and ED-1 positivity in myocardium at risk in rats with NCD and HCD in the sham, CS, and CS plus tetrahydrobiopterin (BH₄) groups at one day and one week (n = 7 each) and 12 weeks after surgery (n = 10 to 13, but n = 10 each for Bonferroni’s post-hoc comparisons). *p < 0.01, p < 0.05 vs. corresponding sham; p < 0.01 BH₄ vs. corresponding CS without BH₄; p < 0.01 vs. corresponding NCD group. Abbreviations as in Figures 1 and 4.

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