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Figure 5 Restitution properties in ACH. (A) An example of APDs and diastolic intervals (DIs) measured using the dynamic restitution protocols (DI = 840 ms, APD₉₀ = 160 ms) at a pacing CL of 1 s. (B) Representative AP restitution curves and R_t (the steepest slope of the restitution curve) from PS before (black circles, R_t = 0.75) and after (open circles, R_t = 0.22) exposure to ACH. Insert shows the linear regression (R_t) of the shortest DIs preceding refractoriness. Dashed line represents unitary slope. (C) Mean values and standard errors of R_t from LA (black), PS (striped), and DS (open) before and after ACH (n = 12). *p < 0.05 for comparisons before and after ACH. (D) Suppression of AP alternans by ACH at a pacing CL of 130 ms (recorded from PS). ACH = 10^–7 mol/l for all. Other abbreviations as in Figures 1 through 3.

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