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Figure 4 Influence of vascular endothelial growth factor (VEGF) on SH2-domain containing tyrosine phosphatase-1 (SHP-1) activity and superoxide production. (A) Stimulation with VEGF (10 ng/ml) enhanced basal phosphatase activity of SHP-1 in human umbilical vein endothelial cells (HUVEC). (B) VEGF (10 ng/ml) also increased HUVEC O2·– release, which was further enhanced when SHP-1 was knocked down using antisense oligodesoxynucleotide (AS-ODN). *, **Significantly different vs. control at p < 0.05 and p < 0.01, respectively; #significantly different vs. VEGF at p < 0.05.
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