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Figure 1 Local angiotensin-converting enzyme (ACE) and angiotensin II type 1 receptor (AT-1R) activities are increased in stenotic aortic valves. (A) ACE autoradiography images of a normal and a stenotic aortic valve. (B) Quantitative analysis of ACE autoradiography levels in normal (n = 11) and stenotic (n = 11) aortic valves. (C) Quantitative analysis of AT-1R autoradiography showed 5.5-fold increase (p < 0.05) in the level of AT-1R in stenotic aortic valves (n = 11) compared with control valves (n = 11). Results are mean values ± SD. *p < 0.05; ***p < 0.001.
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