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Figure 4 Immunolocalization of fibrillar collagen type III by a three-layer immunoperoxidase technique. Sham-operated animals demonstrated constitutive collagen type III expression throughout the myocardium (a). In contrast, myocardium from myocardial infarction (MI) animals demonstrated increased deposition of collagen type III in both the non-infarct and peri-infarct regions (b,d) and in the infarct region (f). The MI animals treated with RWJ-67657 demonstrated similar extents of collagen type III distribution compared with vehicle-treated MI animals (c, e, g). (Magnification: x200).
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