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Figure 2 (A) Changes in the passive component of diastole (i.e., shift of end-diastolic pressure-volume relationship [EDPVR]). A leftward/upward-shifted EDPVR (decreased ventricular capacitance) results in a need for increased filling pressure to achieve filling volumes necessary for the heart to generate a normal stroke volume and blood pressure. Conversely, a rightward/downward-shifted EDPVR (increased ventricular capacitance) occurs in all forms of dilated cardiomyopathy and is commonly referred to as "ventricular remodeling." (B) The EDPVR provides the lower boundary for the instantaneous pressure-volume loop. At low filling pressures (black loop), the filling phase of the loop (arrow) may coincide with EDPVR. At high filling pressures (red), however, the filling phase (arrow) may be elevated significantly abovethe EDPVR, even when tau is normal. This is a response of any normal heart and does not necessarily indicate diastolic dysfunction. LV = left ventricle.
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