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Figure 3 Kinetics of peak pulmonary vasodilatory effects of the different phosphodiesterase-5 (PDE5) inhibitors. Deviations from the pre-intervention baseline values (point estimates of median difference [percentage of baseline = symbols], with exact 95% confidence intervals [CIs] [vertical bars]) for PVRI over time; also displayed are point estimates of median difference effects (percentage of baseline = symbols), with exact 95% CIs (horizontal bars). The changes are noted in response to sildenafil (Sil 50 mg = red square), vardenafil (Vard 10 mg = solid blue diamond; Vard 20 mg = open blue diamond), and tadalafil (Tada 20 mg = green hourglass; Tada 40 mg = open green inverted triangle; Tada 60 mg = solid green inverted triangle). The p value indicates significant difference of time to peak pulmonary vasodilation between the different therapeutic agents, as determined by analysis of variance (#different from Tadalafil 40 mg group; p < 0.05, Scheffé post-test). There was no difference in the magnitude of response among the treatment groups (p = 0.185). PVRI = pulmonary vascular resistance index.
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