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Figure 6 Photomicrographs of porcine coronary arteries at 28 days after the implantation of Quannum-DS (Quanam Medical Corp., Santa Clara, California) stents. These images show neointimal stimulation by high-dose taxane in these stents. Similar results occurred in the SCORE clinical trial. Low power histomorphometry of mid-stent cross-section shows marked vessel lumen narrowing from neointimal hyperplasia. (B, C, and D) Rampant inflammation at sites of the polymer-drug combination in these vessels is shown. Several areas of granuloma and hemorrhage (B) are present. The inflammation was likely a major cause of the neointimal thickening. (E) Cine-film frame of Quannum stent showing marked in-stent restenosis.
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