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Figure 5 Porcinecoronary arteries at 28 days (top) and 90 days (bottom) after actinomycin-D eluting stent placement. The 28-day data show substantial residual fibrin, inadequate vascular healing, but little mature neointima. At 90 days, there is a marked increase in neointimal thickening, greater than control, which occurred over time. The graph at lower right shows neointimal thickness measures for 90-day control and 10-µg datasets. The ACTION trial of actinomycin-D elution was stopped prematurely because of elevated major adverse clinical event rates due in part to abnormally high late loss.
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