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Figure 2 (A) Original tracings showing vasomotor responses in isolated descending thoracic arteries from wild-type mice (WT), untreated apo E-null mice (ApoE), and ApoE mice treated with high-dose (80 mg/kg/dose) apo A-IMilano/DPPC complex (ApoE + apo A-IM/DPPC 80) and DPPC alone (ApoE + DPPC). Dilator responses to intraluminal perfusion of endothelium-dependent agonist, acetylcholine (Ach), and endothelium-independent agonist, sodium nitroprusside (SNP) were examined in arteries preconstricted with serotonin (5-HT, 1 µM) administered abluminally. (B) Line plots showing concentration response to Ach (top panel) and sodium nitroprusside (bottom panel). Values (mean ± SEM) are percent change from a preconstricted diameter of 1.12 ± 0.02 mm. *p < 0.001 vs. ApoE, analysis of variance. Open circles = wild-type (n = 5); open triangles = ApoE + apo A-IM/DPPC 80 (n = 10); solid triangles = ApoE + apo A-IM/DPPC 20 (n = 10); open squares = ApoE + apo A-IM 80 (n = 5); solid diamonds = ApoE + DPPC (n = 5); solid circles = ApoE (n = 6).
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