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Figure 2 (A) Comparison of mean ± SEM of serum aldosterone measured in both groups at implantation (yellow), at day 14 of pacing (red), and at sacrifice (purple). Serum aldosterone in placebo animals did not increase at day 14 (n = 11), while aldosterone increased significantly in furosemide-treated animals both compared with implant and compared with placebo (n = 9, *p < 0.05 compared with implantation; #p < 0.05 with respect to placebo). (B) Comparison of mean ± SEM of serum norepinephrine measured in both groups at implantation (yellow), at day 14 of pacing (red), and at sacrifice (purple). Serum norepinephrine increased equally in both placebo- and furosemide-treated animals at day 14 (n = 11, *p < 0.05 compared with implantation).
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