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Figure 5 Cardiac functional recovery in untreated fibroblast growth factor (FGF) and wild-type (WT) control hearts. In addition, this figure demonstrates the hemodynamic effects of pretreatment of FGF hearts with selective inhibitors of tyrosine kinases (FGF/LA), PKC (FGF/CHE), and FGF-R1 (FGF/SU). (A) Aortic flow. (B) Left ventricular developed pressure. (C) Maximal rate of positive pressure development (dP/dtmax in mm Hg/s2). (D) Left ventricular diastolic pressure. *p < 0.05 compared with WT, {dagger}p < 0.05 compared with FGF. Che = chelerythrine chloride; LA = lavendustin A; SU = SU5402. "Basal" indicates the preischemic period, "L" indicates Langendorff reperfusion, and "+15, +25, +35, +60 min" indicates 15, 25, 35, and 60 min of antegrade reperfusion, respectively.





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