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Figure 1 Individual effects of purified antibodies (IgG 300 mg/l) on isolated field-stimulated rat cardiomyocytes. Changes of Ca2+ transients (A) and systolic cell shortening (B) during superfusion (% changes from baseline): antibodies from plasma of healthy blood donors (controls, n = 45). Antibodies from dilated cardiomyopathy (DCM) patients that induced cardiodepressant effects (cardiodepressant group, n = 29). Antibodies from DCM patients that did not influence Ca2+ transients and systolic cell shortening (non-cardiodepressant group, n = 16). ###p < 0.001 significantly different from controls; +++p < 0.001 significantly different from non-cardiodepressant group.
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