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Figure 2 Platelet aggregation induced by 0.6 mmol/l arachidonic acid was completely inhibited by prolonged administration of NCX-4016, aspirin (ASA), and NCX-4026 plus ASA (A). This was accompanied by a statistically significant reduction in the serum concentration of thromboxane (TX) B2, index of cyclooxygenase activity in platelets (B), and urinary excretion of 11-dehydro(dh)-TXB2, index of in vivo TXA2 biosynthesis (C). Means and standard errors, n = 12; *p < 0.0001 vs. placebo.
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