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Figure 1 (A) Extent of left ventricular (LV) [¹¹C]meta-hydroxyephedrine ([¹¹C]HED) retention deficits in different subject groups. Normalized [¹¹C]HED retention data are displayed as polar coordinate maps of relative tracer activity ([¹¹C]/[¹³N]). The "extent" of the heterogeneity is expressed as the percentage of sectors in the polar map that are abnormal, i.e., z_i >2.5. p < 0.01 early microangiopathy (DMA+) versus diabetic control subjects (DC). Horizontal bars = mean value. (B) Left ventricular [¹¹C]HED retention is globally decreased in a DMA+ subject. Quantitative assessment of LV [¹¹C]HED retention (expressed as a retention index [RI]) demonstrated reduced retention in all LV sectors in a DMA+ subject (open plot) compared with the values obtained in nondiabetic control subjects (shaded plot).

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