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Figure 3 Cine cardiac magnetic resonance (CMR) images of hypertrophic cardiomyopathy (HCM) patients with TNNI3 mutations (30). A wide range of HCM was present including: (A) asymmetrical anteroseptal hypertrophy (Arg162Gln), (B) apical hypertrophy (Arg162Gln), (C) midcavity obstruction (Arg145Trp), (D) extreme biventricular hypertrophy (Arg141Gln), (E) "end-stage dilation" (Arg186Gln), and (F) restrictive cardiomyopathy in a child six years of age (de novo Lys178Glu) as recently reported (did not participate in this study) (32). CMR images: (A and B) From left to right: four-chamber, basal short-axis, and apical short-axis, all in diastole; (C to F) four-chamber systole, four-chamber diastole, short-axis diastole. (A and B) first image = four-chamber view, diastole; second image = cross-sectional view, papillary muscle level, diastole; third image = cross-sectional view, apical level, diastole. (D to F) first image = four-chamber view, systole; second image = four-chamber view, diastole; third image = papillary muscle level, diastole. LA = left atrium; LV = left ventricle; RA = right atrium; RV = right ventricle.
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