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Figure 4 Reduction of mitral regurgitation with optimized sequential biventricular pacing (BVP). Pre-implant effective regurgitant orifice area (EROA): 31 mm²; simultaneous BVP EROA: 22 mm²; sequential BVP with right ventricular (RV) pre-activation of 40 ms EROA: 21 mm²; optimized sequential BVP with left ventricular (LV) pre-activation of 40 ms EROA: 10 mm².