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Figure 2 Heart weight/body weight indices of WT and OPN–/– mice at baseline and after three weeks of AngII infusion. Angiotensin II causes hypertrophy as detected by increased heart/body weight ratio in control but not in OPN–/– mice. Heart-to-body-weight ratio of WT is significantly increased in the AngII-treated group compared with the control sham-infused group (*p < 0.001), whereas heart-to-body-weight ratio is not significantly increased in either of the treated OPN–/– groups, even when 3 µg/kg/min AngII infusion affected BPs greater in both absolute value and percent change versus baseline compared with WT control animals. White bars = control; hatched bars = AngII, 2.5 µg/kg/min; black bars = 3 µg/kg/min. Abbreviations as in Figure 1.
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